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c-kit Receptor and Ligand (Steel Factor) Articles

Williams, D. E., Eisenman, J. , Baird, A. , Rauch, C. , Van Ness, K., March, C.J., Park, L.S., Martin, U., Mochizuki, D.Y., Boswell, H. S., Burgess, G. S., Cosman, D., and Lyman, S.D. Identification of a ligand for the c-kit proto-oncogene. Cell, 63, 167-174, 1990.

Copeland, N.G., Gilbert, D.J., Cho, B.C., Donovan, P.J., Jenkins, N.A., Cosman, D., Anderson, D., Lyman, S.D., and Williams, D.E. Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles. Cell 63, 175-183, 1990.

Anderson, D. M., Lyman, S. D., Baird, A., Wignall, J.M., Eisenman, J., Rauch, C., March, C.J., Boswell, H. S., Gimpel, S.D., Cosman, D., and Williams, D. E. Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms. Cell 63, 235-243, 1990.

Broxmeyer, H.E., Cooper, S., Lu, L., Hangoc, G., Anderson, D., Cosman, D. Lyman, S.D., and Williams, D.E. Effect of murine mast cell growth factor (c-kit proto-oncogene ligand) on colony formation by human marrow hematopoietic progenitor cells. Blood 77, 2142-2149, 1991.

Broxmeyer, H.E., Hangoc, G., Cooper, S., Anderson, D., Cosman, D., Lyman, S.D., and Williams, D.E. Influence of murine mast cell growth factor (c-kit ligand) on colony formation by mouse marrow hematopoietic progenitor cells. Exp. Hematol. 19, 143-146, 1991.

Brannan, C.I., Lyman, S.D., Williams, D.E., Eisenman, J., Anderson, D.M., Cosman, D., Bedell, M. A., Jenkins, N. A., and Copeland, N. G. Steel-Dickie mutation encodes c-kit ligand lacking transmembrane and cytoplasmic domains. Proc. Natl. Acad. Sci. 88, 4671-4674, 1991.

Keshet, E., Lyman, S.D., Williams, D.E., Anderson, D.M., Jenkins, N. A., Copeland, N. G., and Parada, L.F. Embryonic RNA expression patterns of the c-kit receptor and its cognate ligand suggest multiple functional roles in mouse development. EMBO J. 10, 2425-2435, 1991.

Miller, B.A., Perrine, S. P., Bernstein, A., Lyman, S.D., Williams, D.E., Bell, L. L., and Olivieri, N. Influence of Steel factor on hemoglobin synthesis in sickle cell disease. Blood 79, 1861-1868, 1992.

Wang, C, Koistinen, P., Yang, G.S., Williams, D.E., Lyman, S.D., Minden, M.D., and McCulloch, E. A. Mast cell growth factor, the ligand for the receptor encoded by c-kit, effects the growth and ara-C sensitivity of the blast cells of acute myeloblastic leukemia. Leukemia 5, 493-499, 1991.

Koistinen, P., Wang, C., Yang, G.S., Wang, Y.-F., Curtis, J.E., Williams, D.E., Lyman, S.D., Minden, M.D., and McCulloch, E.A. OCI/AML-4, an acute myeblastic leukemia cell line: Regulation and response to cytosine arabinoside. Leukemia 5, 704-711, 1991.

Williams, D.E., Anderson, D.M., and Lyman, S.D. Identification and characterization of a ligand for the c-kit proto-oncogene. The Regulation of Hemoglobin Swithching. Proceedings of the 7th Meeting on Hemoglobin Switching. G. Stamatoyannopoulos and A. Nienhuis, Eds. Johns Hopkins University Press, Baltimore, MD. pp. 454-459, 1991.

Rottapel, R., Reedijk, M., Williams, D.E., Lyman, S.D., Anderson, D. M., Pawson, T., and Bernstein, A. The Steel/W signal transduction pathway: Kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor. Mol. Cell. Biol. 11, 3043-3051, 1991.

Anderson, D., Williams, D. E., Tushinski, R., Gimpel, S., Eisenman, J., Cannizzaro, L.A., Aronson, M, Croce, C.M, Huebner, K., Cosman, D. and Lyman, S.D. Alternate splicing of mRNAs encoding human mast cell growth factor and localization of the gene to chromosome 12q22-24. Cell Growth and Differentiation 2, 373-378, 1991.

Reith, A.D., Ellis, C., Lyman, S.D., Anderson, D.M., Williams, D.E., Bernstein, A., and Pawson, T. Signal transduction by normal isoforms and W mutant variants of the kit receptor tyrosine kinase. EMBO J., 10, 2451-2459, 1991.

Funasaka, Y, Boulton, T., Cobb, M., Yarden, Y., Fan, B., Lyman, S. D., Williams, D. E., Anderson, D. M., Zakut, R., Mishima, Y., and Halaban, R. c-kit kinase induces a cascade of protein tyrosine phosphorylation in normal human melanocytes in response to mast cell growth factor and stimulates mitogen activated protein kinase but is down-regulated in melanomas. Mol. Biol. Cell 3, 197-209, 1992.

Olivieri, N. F., Grunberger, T., Ben-David, Y., Ng, J., Williams, D. E., Lyman, S. D., Anderson, D. M., Axelrad, A.A., Correa, P., Bernstein, A., and Freedman, M. H. Diamond-Blackfan anemia: Heterogenous response of hematopoietic progenitor cells in vitro to the protein product of the Steel locus. Blood 78, 2211-2215, 1991.

Williams, D.E., Fletcher, F.A., Lyman, S.D., and de Vries, P. Cytokine regulation of hematopoietic stem cells. Seminars in Immunology 3, 391-396, 1991.

Dolci, S., Williams, D.E., Ernst, M. K., Resnick, J. L., Brannan, C.I., Lock, L.F., Lyman, S.D., Boswell, H. S. and Donovan, P. J. Requirement for mast cell growth factor for primordial germ cell survival in culture. Nature 352, 809-911, 1991.

Lyman, S. D. and Williams, D. E. Alternate splicing of mRNAs that encode mast cell growth factor and the c-kit proto-oncogene: Potential effects on protein interactions, pp. 183-193, in Blood Cell Growth Factors: Their Present and Future Use in Hematology and Oncology. Martin Murphy, Jr., (Ed.), Alpha Med Press , Dayton, OH 1991.

Williams, D. E. and Lyman, S. D. Characterization of the gene-product of the Steel locus. Progress in Growth Factor Research 3, 235-242, 1991.

Lyman, S. D. and Williams, D. E. Biological activities and potential therapeutic uses of Steel factor: A new growth factor active on multiple hematopoietic lineages. Amer. J..Pediatr. Hematol. Oncol. 14, 1-7, 1992.

Williams, D. E., Foxworthe, D., Teepe, M., Lyman, S. D., Anderson, D., and Eisenman, J. Recombinant murine steel factor stimulates in vitro production of Granulocyte-Macrophage progenitor cells. J. Cell. Biochem. 50, 221-226, 1992.

Murphy, M., Reid, K., Williams, D. E., Lyman, S. D., and Bartlett, P. F. Steel factor is required for maintenance, but not differentiation, of melanocyte precursors in the neural crest. Developmental Biology, 153, 396-401, 1992.

Alexander, W.S. , Lyman, S. D., and Wagner, E.F. Expression of functional c-kit receptors rescues the genetic defect of W mutant mast cells. EMBO J. 10, 3683-3691, 1991.

Williams, D. E. and Lyman, S. D. Molecular and cellular biology of mast cell growth factor: The gene product of the murine Steel locus. Behring Institute Mitt. 90, 23-27, 1991.

Tsuji, K., Lyman, S.D., Sudo, T., Clark, S.C., and Ogawa, M. Enhancement of murine hemopoiesis by synergistic interactions between steel factor (ligand for c-kit), interleukin 11, and other early-acting factors in culture. Blood 79, 2855-2860, 1992.

Williams, D. E., de Vries, P., Namen, A.E., Widmer, M.B., and Lyman, S.D. The Steel factor. Developmental Biol. 151, 368-376, 1992.

Brannan, C.I., Bedell, M.A., Resnick, J.L., Eppig, J.J., Handel, M.A., Williams, D.E., Lyman, S.D., Donovan, P.J., Jenkins, N.A., and Copeland, N.G. Developmental abnormalities in Steel17H mice result from splicing defect in the steel factor cytoplasmic tail. Genes and Development 6, 1832-1842, 1992.

Zakut, R., Perlis, R., Eliahu, S., Yarden, Y., Givol, D., Lyman, S.D., and Halaban, R. Kit ligand inhibits the growth of kit expressing melanoma cells. Oncogene 8, 2221-2229, 1993.

Hu, Q., Trevisan, M., Xu, Y., Dong, W., Berger, S., Lyman, S.D., Williams, D.E., and Minden, M.D.. The effect of murine c-kit on the leukaemogenic potential of 32D cells. J. Clin. Invest. 95, 2530-2538, 1995.

Williams, D. E. and Lyman, S. D. Biology of the Steel factor, pp.5-10, in Current Opinion in Hematology, John Adamson, (Ed.) Current Science, Philadelphia, PA , 1993.

Williams, D.E., and Lyman, S.D. Steel factor, in Human Cytokines: Handbook for Basic and Clinical Research, Vol. 2, pp. 316-330, Edited by B.B. Aggarwal and J.U. Gutterman, Blackwell Science Press, Boston, 1996.

Huang, S., Luca, M., Gutman , M., McConkey, D.J., Langley, K.E., Lyman, S.D., and Bar-Eli, M. Enforced c-kit expression renders highly metastatic human melanoma cells susceptible to stem cell factor-induced apoptosis and inhibits their tumorigenic and metastatic potential. Oncogene 13, 2339-2347, 1996.

Lyman, S.D., Mire-Sluis, A. and Gliniak, B. The Steel Factor/kit Ligand/Stem Cell Factor, in Cytokines, A. Mire-Sluis and R. Thorpe, Editors, Academic Press, pp. 297-320, 1998.