Flt3 Receptor and Ligand Articles
Lyman, S.D., James, L.,
Sleath, P.R., Zappone, J., Beckmann, M.P., and Bird, T.
Characterization of the protein encoded by the flt3(flk2)
receptor-like tyrosine kinase gene. Oncogene 8, 815-822,
1993.
Lyman,
S.D., James, L.,
VandenBos, T., de Vries, P., Brasel, K., Gliniak, B.,
Hollingsworth, L. T. , Picha, K.S., McKenna, H.J., Splett,
R.R., Fletcher, F.A., Maraskovsky, E., Farrah, T.,
Foxworthe, D., Williams, D.E., and Beckmann, M.P. Molecular
cloning of a ligand for the flt3/flk-2 tyrosine kinase
receptor - A proliferative factor for primitive
hematopoietic cells. Cell 75, 1157-1167, 1993.
Lyman,
S.D., James, L.,
Johnson, L., Brasel, K., Escobar, S.S., Downey, H., de
Vries, P., Splett, R.R., Beckmann, M.P., and McKenna, H.
Cloning of the human homologue of the murine flt3 ligand: A
growth factor for early hematopoietic progenitor cells.
Blood 83, 2795-2801, 1994.
Lyman,
S.D., James, L.,
Escobar, S., Downey, H., de Vries, K., Brasel, K.,
Stocking, K., Beckmann, M.P., Copeland, N.G., Cleveland,
L.S., Jenkins, N.A., and Davison, B. Identification of
soluble and membrane bound isoforms of the murine flt3
ligand generated by alternative splicing of mRNAs. Oncogene
10, 149-157, 1995.
Lyman,
S.D., Brasel, K.,
Rousseau, A.-M., and Williams, D.E. The flt3 ligand: A
hematopoietic stem cell factor whose activities are
distinct from steel factor. Stem Cells 12, 99-110, 1994.
Lyman,
S.D. and Williams, DE.
Biology and Potential Clinical Applications of flt3 ligand.
Current Opinion in Hematology 2, 177-181, 1995.
Lyman,
S.D., Stocking, K.,
Davison, B. Fletcher, F., Johnson, L., and Escobar, S.S.
Structural analysis of human and murine flt3 ligand genomic
loci. Oncogene 11, 1165-1172, 1995.
Lyman,
S.D. Biology of flt3
ligand and receptor. Int. J. Hematol. 62, 63-73, 1995.
Broxmeyer,
H.E., Lu, L., Cooper, S., Ruggierei, L., Li, Z.-H.,
and
Lyman, S.D. Flt3 ligand
stimulates/costimulates the growth of myeloid
stem/progenitor cells. Exp. Hematol. 23, 1121-1129, 1995.
Hirayama,
F.,
Lyman, S.D., Clark, S.C., and
Ogawa, M. The flt3 ligand supports proliferation of
lymphohemopoietic progenitors and early B-lymphoid
progenitors. Blood 85, 1762-1768, 1995.
Jacobsen,
S.E.W., Okkenhaug, C., Myklebust, J., Veiby, O.P.,
and
Lyman, S.D. The flt3 ligand
potently and directly stimulates the growth and expansion
of primitive murine bone marrow cells in vitro: Synergistic
interactions with Interleukin (IL) 11, IL-12, and other
hematopoietic growth factors. J. Exp. Med., 181, 1357-1363,
1995.
Jacobsen,
S.E.W., Veiby, O.P., Myklebust, J., Okkenhaug, C,
and
Lyman, S.D. Ability of flt3
ligand to stimulate the in vitro growth of primitive murine
hematopoieitic progenitors is potently and directly
inhibited by transforming growth factor-β and tumor-necrosis
factor-α. Blood, 87,
5016-5026, 1996.
Rusten,
L.S.,
Lyman, S.D., Veiby, O.P., and
Jacobsen, S.E.W. The flt3 ligand is a direct and potent
stimulator of the growth of primitive and committed human
CD34+ bone marrow progenitor cells in vitro. Blood 87,
1317-1325, 1996.
Veiby,
O.P., Jacobsen, F.W., Cui, L.,
Lyman, S.D., and Jacobsen,
S.E.W. The flt3 Ligand promotes the survival of primitive
hematopoietic progenitor cells with myeloid as well as
B-lymphoid potential: suppression of apoptosis and
counteraction by TNF-α and
TGF-β. J. Immunol. 157,
2953-2960, 1996.
McKenna,
H.J., de Vries, P., Brasel, K.,
Lyman, S.D., and Williams,
D.E. Effect of flt3 ligand on the ex vivo expansion of
human CD34+
hematopoietic
progenitor cells. Blood 86, 3413-3420, 1995.
Brasel,
K., Escobar, S., Anderberg, R., de Vries, P., Gruss, H.-J.,
and
Lyman, S.D. Expression of the
flt3 receptor and its ligand on hematopoietic cells.
Leukemia 9, 1212-1218, 1995.
Gabbianelli,
M., Pelosi, E., Montesoro, E., Valtieri, M., Lucheti, L.,
Samoggia, P., Vitelli, L., Barberi, T., Testa, T.,
Lyman, S.D., and Peschle, C.
Multi-level effects of flt3 ligand on human hematopoiesis:
expansion of putative stem cells and proliferation of
granulomonocytic progenitors/monocytic precursors. Blood
86, 1661-1670, 1995.
Lyman,
S.D., Seaberg, M.,
Hanna, R., Abkowitz, J.L., Prchal, J., Schultz, J., and
Shahidi, N.T. Plasma/serum levels of Flt3 ligand are low in
normal individuals and are highly elevated in patients with
Fanconi anemia and acquired aplastic anemias. Blood 86,
4091-4096, 1995.
Eder,
M., Hemmati, P., Kalina, U., Ottmann, O.G., Hoelzer,
D.,
Lyman, S.D., and Ganser, A.
Effects of flt3 ligand and interleukin-7 on in vitro growth
of acute lymphoblastic leukemia cells. Exp.. Hematology 24,
371-377, 1996.
Ray,
R.J., Paige, C.J., Furlonger, C.,
Lyman, S.D., and Rottapel, R.
Flt3 ligand supports the differentiation of early B cell
progenitors in the presence of Interleukin-11 and
Interleukin-7. Eur. J. Immunol. 26, 1504-1510, 1996.
McKenna,
H.J., Smith, F.O., Brasel, K.,Hirschstein, D., Bernstein,
I.D.,
Lyman, S.D., and Williams,
D.E. Effects of flt3 ligand on acute myeloid and
lymphocytic leukemic blast cells from children. Exp.
Hematol. 24, 378-385, 1996.
Fujimoto,
K.,
Lyman, S.D., Hirayama, F., and
Ogawa, M. Isolation and characterization of primitive
hematopoietic progenitors of murine fetal liver. Exp.
Hematol. 24, 285-290, 1996.
Broxmeyer, H.E., Cooper, S., Etienne-Julan, M., Braun, S.,
Lu, L.,
Lyman, S.D., and Srivastava,
A. Cord blood
hematopoietic stem/progenitor cell growth and gene
transduction using adeno-associated and retroviral vectors.
Ontogeny of Hematopoiesis (Proceedings of the colloquium on
"Foetal and neonatal hematopoiesis and the mechanisms of
bone marrow failure". John Libbey Eurotext Limited,
Montrouge, France) 235, 109-114, 1995.
Ohishi,
K., Katayama, N., Itoh, R., Mahmud, N., Miwa, H., Kita, K.,
Minami, N., Shirakawa, S.,
Lyman, S.D., and Shiku, H.
Accelerated cell cycling of hematopoietic progenitors by
the flt3 ligand that is modulated by transforming growth
factor-β. Blood 87,
1718-1727, 1996.
Takahira,
H.,
Lyman, S.D., and Broxmeyer,
H.E. Flt3 ligand prolongs survival of
CD34+++
human
umbilical cord blood myeloid progenitors in serum-depleted
culture medium. Ann. Hematol. 72, 131-135, 1996.
Lisovsky,
M., Braun, S.E., Ge, Y., Takahira, H., Lu, L., Savchenko,
V.G.,
Lyman, S.D., and Broxmeyer,
H.E. Flt3 ligand production by human bone marrow stromal
cells. Leukemia 10, 1012-1018, 1996.
Veiby,
O.P.,
Lyman, S.D., and Jacobsen,
S.E.W. Combined signaling through interleukin-7 receptors
and flt3 but not c-kit potently and selectively promotes
B-cell commitment and differentiation from uncommitted
murine bone marrow progenitor cells. Blood 88, 1256-1265,
1996.
Hjertson,
M., Sundstrom, C.,
Lyman, S.D., Nilsson, K., and
Nilsson, G. Stem cell factor, but not flt3 ligand, induces
differentiation and activation of human mast cells. Exp.
Hematol. 24, 748-754, 1996.
McKenna,
H.J. and
Lyman, S.D. Biology of flt3
ligand, a novel regulator of hematopoietic stem and
progenitor cells. in Bone Marrow
Transplantation: Basic and Clinical
Studies. (Ikehara, S.,
Takaku, F. and Good, R.A. editors). Springer-Verlag Tokyo,
85-93, 1996.
Wodnar-Filipowicz,
A.,
Lyman, S.D., Gratwohl, A.,
Tichelli, A., Speck, B., and Nissen, C. Flt3 ligand level
reflects hematopoietic progenitor cell function in aplastic
anemia and chemotherapy-induced bone marrow aplasia. Blood
88, 4493-4499, 1996.
Maraskovsky,
E., Brasel, K., Teepe, M., Roux, E.,
Lyman, S.D., Shortman, K.D.,
and McKenna, H.J. Dramatic increase in the numbers of
functionally mature dendritic cells in Flt3 ligand-treated
mice: multiple dendritic cell subpopulations identified. J.
Exp. Med. 184, 1953-1962, 1996.
Turner,
A.M., Lin, N.L., Issarachai, S.,
Lyman, S.D., and Broudy, V.
FLT3 receptor expression on the surface of normal and
malignant human hematopoietic cells. Blood 88, 3383-3390,
1996.
Ramsfjell,
V., Borge, O.J., Veiby, O.P., Cardier, J., Murphy Jr.,
M.J.,
Lyman, S.D., Lok, S., and
Jacobsen, S.E.W. Thrombopoietin, but not erythropoietin,
directly stimulates multilineage growth of primitive murine
bone marrow progenitor cells in synergy with early acting
cytokines: Distinct interactions with the ligands for
c-kit
and
FLT3. Blood 88, 4481-4492, 1996.
Brasel,
K., McKenna, H.J., Morrissey, P.J., Charrier, K., Morris,
A.E., Lee, C.C., Williams, D.E., and
Lyman, S.D. Hematologic effects
of flt3 ligand in vivo in mice. Blood 88, 2004-2012, 1996.
Ku,
H., Hirayama, F., Kato, T., Miyazaki, H., Aritomi, M., Ota,
Y., D'Andrea, A.,
Lyman, S.D., and Ogawa, M.
Soluble thrombopoietin receptor (mpl) and granulocyte
colony-stimulating factor receptor directly stimulate
proliferation of primitive hematopoietic progenitors of
mice in synergy with Steel factor or the ligand for
flt3/flk2. Blood, 88, 4124-4131, 1996.
Braun,
S.E., Aronica, S.M., Ge, Y., Takahira, H., Etienne-Julan,
M., Lu. L., Minden, M.,
Lyman, S.D., and Broxmeyer,
H.E. Retroviral mediated gene transfer of Flt3 Ligand
enhances proliferation and MAP kinase activity of AML5
cells. Exp. Hematol. 25, 51-56, 1997.
Ohmizono,
Y., Sakabe, H., Kimura, T., Tanimukai, S., Matsumura,
T.,
Lyman, S.D., and Sonoda, Y.
Thrombopoietin augments ex vivo expansion of human cord
blood derived hematopoietic progenitors in combination with
stem cell factor and flt3 ligand. Leukemia 11, 524-530,
1997.
Yonemura,
Y., Ku, H.,
Lyman, S.D., and Ogawa, M. In
vitro expansion of hemtopoietic progenitors and maintenance
of stem cells: Comparison between flt3/flk-2 ligand and kit
ligand. Blood 89, 1915-1921, 1997.
Sonoda,
Y., Kimura, T., Sakabe, H., Tanimukai, S., Ohmizono, Y.,
Nakagawa, S., Yokota, S.,
Lyman, S.D., and Abe, T. Human
flt3 ligand acts on myeloid as well as multipotential
progenitors derived from purified CD34+
blood
progenitors expressing different levels of c-kit protein.
Eur. J. Haematol. 58, 257-264, 1997.
Papayannopoulou,
T., Nakamoto, B., Andrews, R.G.,
Lyman, S.D., and Lee,
M.Y. In vivo effects of
flt3/flk-2 ligand on mobilization of hemopoietic
progenitors in primates and potent synergistic enhancement
with Granulocyte Colony-Stimulating Factor. Blood 90,
620-629, 1997.
Wodnar-Filipowicz,
A., Chklovskaia, E., Manz, C.Y.,
Lyman, S.D., and Nissen, C.
Effect of flt3 ligand on in vitro growth and expansion of
colony-forming bone marrow cells from patients with
aplastic anemia. Exp. Hematol. 25, 573-581, 1997.
Strobl,
H., Bello-Fernandez, C., Riedl, E., Pickl, W.F., Majdic,
O.,
Lyman, S.D., and Knapp, W.
Flt3 ligand in cooperation with Transforming Growth
Factor-β1 potentiates in
vitro development of Langerhans-type dendritic cells and
allows single-cell dendritic cell cluster formation under
serum-free conditions. Blood 90, 1425-1434, 1997.
Chen,
K., Braun, S.,
Lyman, S., Fan, Y.,
Traycoff, C.M., Wiebke, E.A., Gaddy, J., Sledge, G.,
Broxmeyer, H.E., and Cornetta, K. Antitumor activity and
immunotherapeutic properties of flt3-ligand in a murine
breast cancer model. Cancer Res. 57, 3511-3516, 1997.
Brasel,
K., McKenna, H.J., Charrier, K., Morrisey, P.J., Williams,
D.E., and
Lyman, S.D. Flt3 ligand
synergizes with Granulocyte-Macrophage Colony-Stimulating
Factor or Granulocyte Colony-Stimulating Factor to mobilize
hematopoietic progenitor cells into the peripheral blood of
mice. Blood 90, 3781-3788, 1997.
Dooley,
D.C., Xiao, M., Oppenlander, B.K., Plunkett, J.M.,
and
Lyman, S.D. Flt3 ligand
enhances the yield of primitive cells after ex vivo
cultivation of CD34+ CD38dim
cells
and CD34+ CD38 dim
CD33
dim
HLA-DR+
cells. Blood 90, 3903-3913, 1997.
Bello-Fernandez,
C. Matyash, M., Strobl, H., Pickl W.F., Majdic, O.,
Lyman, S.D., and Knapp, W.
Efficient retrovirus-mediated gene transfer of dendritic
cells generated from CD34+
cord
blood cells under serum-free conditions. Human Gene Therapy
8, 1651-1658, 1997.
Veiby,
O.P., Borge, O.J., Martensson, A., Beck, E.X., Schade,
A.E., Grzegorzewski, K.,
Lyman, S.D., Martensson,
I.-L., and Jacobsen, S.E.W. Bidirectional effect of
Interleukin-10 on early murine B-cell development:
Stimulation of flt3-ligand plus Interleukin-7-dependent
generation of CD19-
proB
cells from uncommitted bone marrow progenitor cells and
growth inhibition of CD19+
proB
cells. Blood 90, 4321-4331, 1997.
Ebihara,
Y., Tsuji, K.,
Lyman, S.D., Sui, X., Yoshida,
M., Muraoka, K., Yamada, K., Tanaka, R., and Nakahata, T.
Synergistic action of flt3 and gp130 signalings in human
hematopoiesis. Blood 90, 4363-4368, 1997.
Buhring,
H.-J., Birnbaum, D., Brasel, K., Civin, C., Gotze,
K.,
Lyman, S.D., Rappold, I., and
Rosnet, O. CD135 (FLT3/FLK2/STK-1) Workshop Panel Report
in Leukocyte Typing
VI (Ed. by T.
Kishimoto et al) pp. 875-879, Garland Publishing, Inc. New
York, 1997.
Maraskovsky,
E., Pulendran, B., Brasel, K., Teepe, M., Roux, E. R,
Shortman, K.,
Lyman, S.D., McKenna, H.
Dramatic numerical increase of functionally mature
dendritic cells in flt3 ligand-treated mice. J. Adv. Exp.
Med. Biol., 417 (Dendritic Cells
in Fundamental and Clinical
Immunology,
Vol. 3), 33-40, 1997.
Kobayashi,
M., Laver, J.H.,
Lyman, S.D., Kato, T.,
Miyazaki, H., and Ogawa, M. Thrombopoietin, steel factor
and the ligand for flt3/flk2 interact to stimulate the
proliferation of human hematopoietic progenitors in
culture. Int. J. Hematol. 66, 423-434, 1997.
Lyman,
S.D., Maraskovsky, E.,
and McKenna, H.J. Flt3 ligand, in The Cytokine
Handbook, 3rd Edition, Angus Thomson,
Editor, Academic Press, pp. 727-752, 1998.
Lyman,
S.D. and Jacobsen,
S.E.W. c-kit
Ligand
and flt3 Ligand: Stem/progenitor cell factors with
overlapping yet distinct activities. Blood 91, 1101-1134,
1998.
Slanicka
Krieger, M., Nissen, C., Manz, C.Y., Toksoz, D.,
Lyman, S.D., and
Wodnar-Filipowicz, A. The membrane-bound isoform of stem
cell factor synergizes with soluble flt3 ligand in
supporting early hematopoietic cells in long-term cultures
of normal and aplastic anemia bone marrow. Exp. Hematol.
26, 365-373, 1998.
Sakabe,
H., Kimura, T., Tanimukai, S., Ohmizono, Y., Yokota, S,
Hodohara,K., Okuda, T, Abe, T.,
Lyman, S.D., and Sonoda, Y.
Haematopoietic action of flt3 ligand on cord blood-derived
CD34-positive cells expressing different levels of flt3 or
c-kit tyrosine kinase receptor: Comparison with stem cell
factor. Eur. J. Haematol. 60, 297-306, 1998.
Graddis,
T.J., Brasel, K, Friend, D., Srinivasan, S.,
Lyman, S.D., March, C.J., and
McGrew, J.T. Structure-function analysis of human flt3
ligand-flt3 receptor interactions using a rapid functional
screen. J. Biol. Chem. 273, 17626-17633, 1998.
Lyman,
S.D. Biologic effects
and potential clinical applications of flt3 ligand.
Current
Opinion in Hematology 5, 192-196, 1998.
Gratwohl,
A., John, L., Baldomero, H., Roth, J, Tichelli, A., Nissen,
C.,
Lyman, S.D., and
Wodnar-Filipowicz, A. Flt-3 ligand provides hematopoietic
protection from total body irradiation in rabbits. Blood
92, 765-769, 1998.
Hawley,
T.S., Fong, A.Z.C., Griesser, H.,
Lyman, S.D., and Hawley, R.G.
Leukemic predisposition of mice transplanted with
gene-modified hematopoietic precursors expressing flt3
ligand. Blood 92, 2003-2011, 1998.
Balduini,
A., Braun, S.E., Cornetta, K.,
Lyman, S.D., and Broxmeyer, H.
Comparative effects of retroviral mediated gene transfer
into primary human stromal cells of flt3 ligand, IL-3, and
GM-CSF on production of cord blood progenitor cells in long
term culture. Stem Cells 16, 37-49, 1999.
Pless,
M., Wodnar-Filipowicz, A., John, L., Baldomero, H.,
Lyman, S.D., Nissen, C, and
Gratwohl, A. Synergy of growth factors during mobilization
of peripheral blood precursor cells with recombinant human
flt3-ligand and Granulocyte Colony-Stimulating Factor in
rabbits. Exp. Hematology 27, 155-161, 1998.
Chklovskaia,
E., Jansen, W., Nissen, C.,
Lyman, S.D., Rahner, C.,
Landmann, L., Wodnar-Filipowicz, A. Mechanism of Flt3
ligand expression in bone marrow failure: translocation
from intracellular stores to the surface of T lymphocytes
following chemotherapy-induced suppression of
hematopoiesis. Blood 93, 2595-2604, 1999.
Zwierzina,
H., Anderson, J.E , Rollinger-Holzinger, I., Torok-Storb,
B., Nuessler, V., and
Lyman, S.D. Endogenous flt3
ligand serum levels are associated with disease stage in
patients with myelodysplastic syndromes. Leukemia 13,
553-557, 1999.
Banu,
N., Deng, B.,
Lyman, S.D., and Avraham, H.
Modulation of hematopoietic progenitor development by flt-3
ligand. Cytokine 11, 679-688, 1999.
McKenna,
H.J., Stocking, K., Miller, B., Brasel, K., De Smedt, T.,
Maraskovsky, E., Maliszewski, C., Lynch, D., Smith, J.,
Pulendran, B., Roux, E., Teepe, M.,
Lyman, S.D., and Peschon, J.
Mice lacking flt3 ligand have deficient hematopoiesis
affecting hematopoietic progenitor cells, dendritic cells,
and natural killer cells. Blood 95, 3489-3497, 2000.
Maraskovsky,
E.,
Lyman, S.D., Maliszewski,
C.R., and Lynch, D.H. Flt-3 and Flt-3 ligand, in
Principles and
Practice of the Biologic Therapy of
Cancer,
3rd
Edition., Steven
Rosenberg, Ed. Lipincott, Williams, and Wilkins,
Philadelphia, 875-889, 2000.
Pfister,
O., Chklovskaia, E., Jansen, W., Meszaros, K., Nissen, C.,
Rahner, C., Hurwitz, N., Bogatcheva, N.,
Lyman, S.D., and
Wodnar-Filipowicz, A. Chronic overexpression of
membrane-bound flt3 ligand by T lymphocytes in severe
aplastic anemia. Br. J. Haematol. 109, 211-220, 2000.
Lyman,
S.D., and McKenna, H.J.
Flt3 ligand, in The Cytokine
Handbook, 4th Edition, Angus Thomson,
Editor, Academic Press, Volume 2, pp. 989-1010, 2003.
