Flt3 Receptor and Ligand Articles
Lyman, S.D., James, L.,
Sleath, P.R., Zappone, J., Beckmann, M.P., and Bird, T.
Characterization of the protein encoded by the flt3(flk2)
receptor-like tyrosine kinase gene. Oncogene 8, 815-822,
1993.
Lyman,
S.D., James, L.,
VandenBos, T., de Vries, P., Brasel, K., Gliniak, B.,
Hollingsworth, L. T. , Picha, K.S., McKenna, H.J.,
Splett, R.R., Fletcher, F.A., Maraskovsky, E., Farrah,
T., Foxworthe, D., Williams, D.E., and Beckmann, M.P.
Molecular cloning of a ligand for the flt3/flk-2 tyrosine
kinase receptor - A proliferative factor for primitive
hematopoietic cells. Cell 75, 1157-1167, 1993.
Lyman,
S.D., James, L.,
Johnson, L., Brasel, K., Escobar, S.S., Downey, H., de
Vries, P., Splett, R.R., Beckmann, M.P., and McKenna, H.
Cloning of the human homologue of the murine flt3 ligand:
A growth factor for early hematopoietic progenitor cells.
Blood 83, 2795-2801, 1994.
Lyman,
S.D., James, L.,
Escobar, S., Downey, H., de Vries, K., Brasel, K.,
Stocking, K., Beckmann, M.P., Copeland, N.G., Cleveland,
L.S., Jenkins, N.A., and Davison, B. Identification of
soluble and membrane bound isoforms of the murine flt3
ligand generated by alternative splicing of mRNAs.
Oncogene 10, 149-157, 1995.
Lyman,
S.D., Brasel, K.,
Rousseau, A.-M., and Williams, D.E. The flt3 ligand: A
hematopoietic stem cell factor whose activities are
distinct from steel factor. Stem Cells 12, 99-110, 1994.
Lyman,
S.D. and Williams, DE.
Biology and Potential Clinical Applications of flt3
ligand. Current Opinion in Hematology 2, 177-181, 1995.
Lyman,
S.D., Stocking, K.,
Davison, B. Fletcher, F., Johnson, L., and Escobar, S.S.
Structural analysis of human and murine flt3 ligand
genomic loci. Oncogene 11, 1165-1172, 1995.
Lyman,
S.D. Biology of flt3
ligand and receptor. Int. J. Hematol. 62, 63-73, 1995.
Broxmeyer,
H.E., Lu, L., Cooper, S., Ruggierei, L., Li, Z.-H.,
and
Lyman, S.D. Flt3 ligand
stimulates/costimulates the growth of myeloid
stem/progenitor cells. Exp. Hematol. 23, 1121-1129, 1995.
Hirayama,
F.,
Lyman, S.D., Clark, S.C.,
and Ogawa, M. The flt3 ligand supports proliferation of
lymphohemopoietic progenitors and early B-lymphoid
progenitors. Blood 85, 1762-1768, 1995.
Jacobsen,
S.E.W., Okkenhaug, C., Myklebust, J., Veiby, O.P.,
and
Lyman, S.D. The flt3 ligand
potently and directly stimulates the growth and expansion
of primitive murine bone marrow cells in vitro:
Synergistic interactions with Interleukin (IL) 11, IL-12,
and other hematopoietic growth factors. J. Exp. Med.,
181, 1357-1363, 1995.
Jacobsen,
S.E.W., Veiby, O.P., Myklebust, J., Okkenhaug, C,
and
Lyman, S.D. Ability of flt3
ligand to stimulate the in vitro growth of primitive
murine hematopoieitic progenitors is potently and
directly inhibited by transforming growth
factor-β and
tumor-necrosis factor-α. Blood, 87,
5016-5026, 1996.
Rusten,
L.S.,
Lyman, S.D., Veiby, O.P.,
and Jacobsen, S.E.W. The flt3 ligand is a direct and
potent stimulator of the growth of primitive and
committed human CD34+ bone marrow progenitor cells in
vitro. Blood 87, 1317-1325, 1996.
Veiby,
O.P., Jacobsen, F.W., Cui, L.,
Lyman, S.D., and Jacobsen,
S.E.W. The flt3 Ligand promotes the survival of primitive
hematopoietic progenitor cells with myeloid as well as
B-lymphoid potential: suppression of apoptosis and
counteraction by TNF-α and
TGF-β. J. Immunol.
157, 2953-2960, 1996.
McKenna,
H.J., de Vries, P., Brasel, K.,
Lyman, S.D., and Williams,
D.E. Effect of flt3 ligand on the ex vivo expansion of
human CD34+
hematopoietic
progenitor cells. Blood 86, 3413-3420, 1995.
Brasel,
K., Escobar, S., Anderberg, R., de Vries, P., Gruss,
H.-J., and
Lyman, S.D. Expression of the
flt3 receptor and its ligand on hematopoietic cells.
Leukemia 9, 1212-1218, 1995.
Gabbianelli,
M., Pelosi, E., Montesoro, E., Valtieri, M., Lucheti, L.,
Samoggia, P., Vitelli, L., Barberi, T., Testa, T.,
Lyman, S.D., and Peschle, C.
Multi-level effects of flt3 ligand on human
hematopoiesis: expansion of putative stem cells and
proliferation of granulomonocytic progenitors/monocytic
precursors. Blood 86, 1661-1670, 1995.
Lyman,
S.D., Seaberg, M.,
Hanna, R., Abkowitz, J.L., Prchal, J., Schultz, J., and
Shahidi, N.T. Plasma/serum levels of Flt3 ligand are low
in normal individuals and are highly elevated in patients
with Fanconi anemia and acquired aplastic anemias. Blood
86, 4091-4096, 1995.
Eder,
M., Hemmati, P., Kalina, U., Ottmann, O.G., Hoelzer,
D.,
Lyman, S.D., and Ganser, A.
Effects of flt3 ligand and interleukin-7 on in vitro
growth of acute lymphoblastic leukemia cells. Exp..
Hematology 24, 371-377, 1996.
Ray,
R.J., Paige, C.J., Furlonger, C.,
Lyman, S.D., and Rottapel,
R. Flt3 ligand supports the differentiation of early B
cell progenitors in the presence of Interleukin-11 and
Interleukin-7. Eur. J. Immunol. 26, 1504-1510, 1996.
McKenna,
H.J., Smith, F.O., Brasel, K.,Hirschstein, D., Bernstein,
I.D.,
Lyman, S.D., and Williams,
D.E. Effects of flt3 ligand on acute myeloid and
lymphocytic leukemic blast cells from children. Exp.
Hematol. 24, 378-385, 1996.
Fujimoto,
K.,
Lyman, S.D., Hirayama, F.,
and Ogawa, M. Isolation and characterization of primitive
hematopoietic progenitors of murine fetal liver. Exp.
Hematol. 24, 285-290, 1996.
Broxmeyer, H.E., Cooper, S., Etienne-Julan, M., Braun,
S., Lu, L.,
Lyman, S.D., and Srivastava,
A. Cord blood
hematopoietic stem/progenitor cell growth and gene
transduction using adeno-associated and retroviral
vectors. Ontogeny of Hematopoiesis (Proceedings of the
colloquium on "Foetal and neonatal hematopoiesis and the
mechanisms of bone marrow failure". John Libbey Eurotext
Limited, Montrouge, France) 235, 109-114, 1995.
Ohishi,
K., Katayama, N., Itoh, R., Mahmud, N., Miwa, H., Kita,
K., Minami, N., Shirakawa, S.,
Lyman, S.D., and Shiku, H.
Accelerated cell cycling of hematopoietic progenitors by
the flt3 ligand that is modulated by transforming growth
factor-β. Blood 87,
1718-1727, 1996.
Takahira,
H.,
Lyman, S.D., and Broxmeyer,
H.E. Flt3 ligand prolongs survival of
CD34+++
human
umbilical cord blood myeloid progenitors in
serum-depleted culture medium. Ann. Hematol. 72, 131-135,
1996.
Lisovsky,
M., Braun, S.E., Ge, Y., Takahira, H., Lu, L., Savchenko,
V.G.,
Lyman, S.D., and Broxmeyer,
H.E. Flt3 ligand production by human bone marrow stromal
cells. Leukemia 10, 1012-1018, 1996.
Veiby,
O.P.,
Lyman, S.D., and Jacobsen,
S.E.W. Combined signaling through interleukin-7 receptors
and flt3 but not c-kit potently and selectively promotes
B-cell commitment and differentiation from uncommitted
murine bone marrow progenitor cells. Blood 88, 1256-1265,
1996.
Hjertson,
M., Sundstrom, C.,
Lyman, S.D., Nilsson, K.,
and Nilsson, G. Stem cell factor, but not flt3 ligand,
induces differentiation and activation of human mast
cells. Exp. Hematol. 24, 748-754, 1996.
McKenna,
H.J. and
Lyman, S.D. Biology of flt3
ligand, a novel regulator of hematopoietic stem and
progenitor cells. in Bone Marrow
Transplantation: Basic and Clinical
Studies. (Ikehara, S.,
Takaku, F. and Good, R.A. editors). Springer-Verlag
Tokyo, 85-93, 1996.
Wodnar-Filipowicz,
A.,
Lyman, S.D., Gratwohl, A.,
Tichelli, A., Speck, B., and Nissen, C. Flt3 ligand level
reflects hematopoietic progenitor cell function in
aplastic anemia and chemotherapy-induced bone marrow
aplasia. Blood 88, 4493-4499, 1996.
Maraskovsky,
E., Brasel, K., Teepe, M., Roux, E.,
Lyman, S.D., Shortman, K.D.,
and McKenna, H.J. Dramatic increase in the numbers of
functionally mature dendritic cells in Flt3
ligand-treated mice: multiple dendritic cell
subpopulations identified. J. Exp. Med. 184, 1953-1962,
1996.
Turner,
A.M., Lin, N.L., Issarachai, S.,
Lyman, S.D., and Broudy, V.
FLT3 receptor expression on the surface of normal and
malignant human hematopoietic cells. Blood 88, 3383-3390,
1996.
Ramsfjell,
V., Borge, O.J., Veiby, O.P., Cardier, J., Murphy Jr.,
M.J.,
Lyman, S.D., Lok, S., and
Jacobsen, S.E.W. Thrombopoietin, but not erythropoietin,
directly stimulates multilineage growth of primitive
murine bone marrow progenitor cells in synergy with early
acting cytokines: Distinct interactions with the ligands
for c-kit
and
FLT3. Blood 88, 4481-4492, 1996.
Brasel,
K., McKenna, H.J., Morrissey, P.J., Charrier, K., Morris,
A.E., Lee, C.C., Williams, D.E., and
Lyman, S.D. Hematologic
effects of flt3 ligand in vivo in mice. Blood 88,
2004-2012, 1996.
Ku,
H., Hirayama, F., Kato, T., Miyazaki, H., Aritomi, M.,
Ota, Y., D'Andrea, A.,
Lyman, S.D., and Ogawa, M.
Soluble thrombopoietin receptor (mpl) and granulocyte
colony-stimulating factor receptor directly stimulate
proliferation of primitive hematopoietic progenitors of
mice in synergy with Steel factor or the ligand for
flt3/flk2. Blood, 88, 4124-4131, 1996.
Braun,
S.E., Aronica, S.M., Ge, Y., Takahira, H., Etienne-Julan,
M., Lu. L., Minden, M.,
Lyman, S.D., and Broxmeyer,
H.E. Retroviral mediated gene transfer of Flt3 Ligand
enhances proliferation and MAP kinase activity of AML5
cells. Exp. Hematol. 25, 51-56, 1997.
Ohmizono,
Y., Sakabe, H., Kimura, T., Tanimukai, S., Matsumura,
T.,
Lyman, S.D., and Sonoda, Y.
Thrombopoietin augments ex vivo expansion of human cord
blood derived hematopoietic progenitors in combination
with stem cell factor and flt3 ligand. Leukemia 11,
524-530, 1997.
Yonemura,
Y., Ku, H.,
Lyman, S.D., and Ogawa, M.
In vitro expansion of hemtopoietic progenitors and
maintenance of stem cells: Comparison between flt3/flk-2
ligand and kit ligand. Blood 89, 1915-1921, 1997.
Sonoda,
Y., Kimura, T., Sakabe, H., Tanimukai, S., Ohmizono, Y.,
Nakagawa, S., Yokota, S.,
Lyman, S.D., and Abe, T.
Human flt3 ligand acts on myeloid as well as
multipotential progenitors derived from purified
CD34+
blood
progenitors expressing different levels of c-kit protein.
Eur. J. Haematol. 58, 257-264, 1997.
Papayannopoulou,
T., Nakamoto, B., Andrews, R.G.,
Lyman, S.D., and Lee,
M.Y. In vivo effects
of flt3/flk-2 ligand on mobilization of hemopoietic
progenitors in primates and potent synergistic
enhancement with Granulocyte Colony-Stimulating Factor.
Blood 90, 620-629, 1997.
Wodnar-Filipowicz,
A., Chklovskaia, E., Manz, C.Y.,
Lyman, S.D., and Nissen, C.
Effect of flt3 ligand on in vitro growth and expansion of
colony-forming bone marrow cells from patients with
aplastic anemia. Exp. Hematol. 25, 573-581, 1997.
Strobl,
H., Bello-Fernandez, C., Riedl, E., Pickl, W.F., Majdic,
O.,
Lyman, S.D., and Knapp, W.
Flt3 ligand in cooperation with Transforming Growth
Factor-β1 potentiates in
vitro development of Langerhans-type dendritic cells and
allows single-cell dendritic cell cluster formation under
serum-free conditions. Blood 90, 1425-1434, 1997.
Chen,
K., Braun, S.,
Lyman, S., Fan, Y.,
Traycoff, C.M., Wiebke, E.A., Gaddy, J., Sledge, G.,
Broxmeyer, H.E., and Cornetta, K. Antitumor activity and
immunotherapeutic properties of flt3-ligand in a murine
breast cancer model. Cancer Res. 57, 3511-3516, 1997.
Brasel,
K., McKenna, H.J., Charrier, K., Morrisey, P.J.,
Williams, D.E., and
Lyman, S.D. Flt3 ligand
synergizes with Granulocyte-Macrophage Colony-Stimulating
Factor or Granulocyte Colony-Stimulating Factor to
mobilize hematopoietic progenitor cells into the
peripheral blood of mice. Blood 90, 3781-3788, 1997.
Dooley,
D.C., Xiao, M., Oppenlander, B.K., Plunkett, J.M.,
and
Lyman, S.D. Flt3 ligand
enhances the yield of primitive cells after ex vivo
cultivation of CD34+ CD38dim
cells
and CD34+ CD38 dim
CD33
dim
HLA-DR+ cells.
Blood 90, 3903-3913, 1997.
Bello-Fernandez,
C. Matyash, M., Strobl, H., Pickl W.F., Majdic,
O.,
Lyman, S.D., and Knapp, W.
Efficient retrovirus-mediated gene transfer of dendritic
cells generated from CD34+
cord
blood cells under serum-free conditions. Human Gene
Therapy 8, 1651-1658, 1997.
Veiby,
O.P., Borge, O.J., Martensson, A., Beck, E.X., Schade,
A.E., Grzegorzewski, K.,
Lyman, S.D., Martensson,
I.-L., and Jacobsen, S.E.W. Bidirectional effect of
Interleukin-10 on early murine B-cell development:
Stimulation of flt3-ligand plus Interleukin-7-dependent
generation of CD19-
proB
cells from uncommitted bone marrow progenitor cells and
growth inhibition of CD19+
proB
cells. Blood 90, 4321-4331, 1997.
Ebihara,
Y., Tsuji, K.,
Lyman, S.D., Sui, X.,
Yoshida, M., Muraoka, K., Yamada, K., Tanaka, R., and
Nakahata, T. Synergistic action of flt3 and gp130
signalings in human hematopoiesis. Blood 90, 4363-4368,
1997.
Buhring,
H.-J., Birnbaum, D., Brasel, K., Civin, C., Gotze,
K.,
Lyman, S.D., Rappold, I.,
and Rosnet, O. CD135 (FLT3/FLK2/STK-1) Workshop Panel
Report in Leukocyte
Typing VI (Ed. by T.
Kishimoto et al) pp. 875-879, Garland Publishing, Inc.
New York, 1997.
Maraskovsky,
E., Pulendran, B., Brasel, K., Teepe, M., Roux, E. R,
Shortman, K.,
Lyman, S.D., McKenna, H.
Dramatic numerical increase of functionally mature
dendritic cells in flt3 ligand-treated mice. J. Adv. Exp.
Med. Biol., 417 (Dendritic
Cells in Fundamental and Clinical
Immunology,
Vol. 3), 33-40, 1997.
Kobayashi,
M., Laver, J.H.,
Lyman, S.D., Kato, T.,
Miyazaki, H., and Ogawa, M. Thrombopoietin, steel factor
and the ligand for flt3/flk2 interact to stimulate the
proliferation of human hematopoietic progenitors in
culture. Int. J. Hematol. 66, 423-434, 1997.
Lyman,
S.D., Maraskovsky,
E., and McKenna, H.J. Flt3 ligand, in The Cytokine
Handbook, 3rd Edition, Angus Thomson,
Editor, Academic Press, pp. 727-752, 1998.
Lyman,
S.D. and Jacobsen,
S.E.W. c-kit
Ligand and flt3
Ligand: Stem/progenitor cell factors with overlapping yet
distinct activities. Blood 91, 1101-1134, 1998.
Slanicka
Krieger, M., Nissen, C., Manz, C.Y., Toksoz, D.,
Lyman, S.D., and
Wodnar-Filipowicz, A. The membrane-bound isoform of stem
cell factor synergizes with soluble flt3 ligand in
supporting early hematopoietic cells in long-term
cultures of normal and aplastic anemia bone marrow. Exp.
Hematol. 26, 365-373, 1998.
Sakabe,
H., Kimura, T., Tanimukai, S., Ohmizono, Y., Yokota, S,
Hodohara,K., Okuda, T, Abe, T.,
Lyman, S.D., and Sonoda, Y.
Haematopoietic action of flt3 ligand on cord
blood-derived CD34-positive cells expressing different
levels of flt3 or c-kit tyrosine kinase receptor:
Comparison with stem cell factor. Eur. J. Haematol. 60,
297-306, 1998.
Graddis,
T.J., Brasel, K, Friend, D., Srinivasan, S.,
Lyman, S.D., March, C.J.,
and McGrew, J.T. Structure-function analysis of human
flt3 ligand-flt3 receptor interactions using a rapid
functional screen. J. Biol. Chem. 273, 17626-17633, 1998.
Lyman,
S.D. Biologic effects
and potential clinical applications of flt3
ligand. Current Opinion
in Hematology 5, 192-196, 1998.
Gratwohl,
A., John, L., Baldomero, H., Roth, J, Tichelli, A.,
Nissen, C.,
Lyman, S.D., and
Wodnar-Filipowicz, A. Flt-3 ligand provides hematopoietic
protection from total body irradiation in rabbits. Blood
92, 765-769, 1998.
Hawley,
T.S., Fong, A.Z.C., Griesser, H.,
Lyman, S.D., and Hawley,
R.G. Leukemic predisposition of mice transplanted with
gene-modified hematopoietic precursors expressing flt3
ligand. Blood 92, 2003-2011, 1998.
Balduini,
A., Braun, S.E., Cornetta, K.,
Lyman, S.D., and Broxmeyer,
H. Comparative effects of retroviral mediated gene
transfer into primary human stromal cells of flt3 ligand,
IL-3, and GM-CSF on production of cord blood progenitor
cells in long term culture. Stem Cells 16, 37-49, 1999.
Pless,
M., Wodnar-Filipowicz, A., John, L., Baldomero,
H.,
Lyman, S.D., Nissen, C, and
Gratwohl, A. Synergy of growth factors during
mobilization of peripheral blood precursor cells with
recombinant human flt3-ligand and Granulocyte
Colony-Stimulating Factor in rabbits. Exp. Hematology 27,
155-161, 1998.
Chklovskaia,
E., Jansen, W., Nissen, C.,
Lyman, S.D., Rahner, C.,
Landmann, L., Wodnar-Filipowicz, A. Mechanism of Flt3
ligand expression in bone marrow failure: translocation
from intracellular stores to the surface of T lymphocytes
following chemotherapy-induced suppression of
hematopoiesis. Blood 93, 2595-2604, 1999.
Zwierzina,
H., Anderson, J.E , Rollinger-Holzinger, I., Torok-Storb,
B., Nuessler, V., and
Lyman, S.D. Endogenous flt3
ligand serum levels are associated with disease stage in
patients with myelodysplastic syndromes. Leukemia 13,
553-557, 1999.
Banu,
N., Deng, B.,
Lyman, S.D., and Avraham, H.
Modulation of hematopoietic progenitor development by
flt-3 ligand. Cytokine 11, 679-688, 1999.
McKenna,
H.J., Stocking, K., Miller, B., Brasel, K., De Smedt, T.,
Maraskovsky, E., Maliszewski, C., Lynch, D., Smith, J.,
Pulendran, B., Roux, E., Teepe, M.,
Lyman, S.D., and Peschon, J.
Mice lacking flt3 ligand have deficient hematopoiesis
affecting hematopoietic progenitor cells, dendritic
cells, and natural killer cells. Blood 95, 3489-3497,
2000.
Maraskovsky,
E.,
Lyman, S.D., Maliszewski,
C.R., and Lynch, D.H. Flt-3 and Flt-3 ligand, in
Principles and
Practice of the Biologic Therapy of
Cancer,
3rd
Edition., Steven
Rosenberg, Ed. Lipincott, Williams, and Wilkins,
Philadelphia, 875-889, 2000.
Pfister,
O., Chklovskaia, E., Jansen, W., Meszaros, K., Nissen,
C., Rahner, C., Hurwitz, N., Bogatcheva, N.,
Lyman, S.D., and
Wodnar-Filipowicz, A. Chronic overexpression of
membrane-bound flt3 ligand by T lymphocytes in severe
aplastic anemia. Br. J. Haematol. 109, 211-220, 2000.
Lyman,
S.D., and McKenna,
H.J. Flt3 ligand, in The Cytokine
Handbook, 4th Edition, Angus Thomson,
Editor, Academic Press, Volume 2, pp. 989-1010,
2003.