Patents, Publications, and Presentations


  • U.S. Patents

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    I am a named inventor on the following 26 United States patents:

    U.S. Patent #5,512,457 – Cytokine designated Elk ligand
    U.S. Patent #5,627,267 – Cytokine designated Elk ligand
    U.S. Patent #5,670,625 – Elk ligand fusion proteins
    U.S. Patent #5,728,813 – Antibodies directed against Elk ligand
    U.S. Patent #5,554,512 – Ligands for Flt3 receptors
    U.S. Patent #5,843,423 – Flt3 ligand stimulation of hematopoietic cells
    U.S. Patent #6,190,655 – Flt3 ligand uses for exogenous gene transfer
    U.S. Patent #6,540,992 – Methods for using elk-L to enhance neuronal survival
    U.S. Patent #6,555,520 – Human TSLP DNA and polypeptides
    U.S. Patent #6,630,143 – Antibodies against flt3 ligand
    U.S. Patent #6,632,424 – Human flt3 ligand
    U.S. Patent #6,762,030 – Ligand for CD7, and methods for use thereof
    U.S. Patent #6,919,206 – Medium containing flt3 ligand for culturing hematopoietic cells
    U.S. Patent #6,994,989 – FLK-1 binding proteins
    U.S. Patent #7,041,282 – Ligands for flt3 receptors
    U.S. Patent #7,045,128 – Antibodies against flt3 ligand
    U.S. Patent #7,288,633 – Modified human thymic stromal lymphopoietin

    U.S. Patent #7,294,331 – Methods of using flt3-ligand in hematopoietic cell transplantation
    U.S. Patent #7,304,144 – Antibodies binding to human TSLP polypeptides

    U.S. Patent #7,329,740 – Flk-1 binding protein
    U.S. Patent #7,405,058 – Human TSLP polypeptides
    U.S. Patent #7,709,217 – Modified human thymic stromal lymphopoietin
    U.S. Patent #7,786,271 – Antibodies that inhibit TSLP activity
    U.S. Patent #7,973,151 – Nucleic acid encoding modified human thymic stromal lymphopoietin
    U.S. Patent #8,444,979 – Antibodies that inhibit TSLP activity
    U.S. Patent #8,598,318 – Modified human thymic stromal lymphopoietin
    U.S. Patent #9,045,558 – Nucleic acids encoding modified human thymic stromal lymphopoietin
    U.S. Patent #9,346,870 – Antibodies that inhibit TSLP activity
  • Peer Reviewed Journal Articles

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    I’ve authored or co-authored 129 scientific articles; these are organized by subject and are listed by topic under the links below. As you can see, I’ve been highly focused on tyrosine kinase receptors and their ligands. More recently I have also published a number of articles on the consulting area that I specialize in, scientific collaborations, along with a number of Op-Ed articles about the biotech industry. These are also listed below:

    Flt3 Receptor and Ligand [68]

    c-kit Receptor and Ligand (Steel Factor)
    [34]

    Ephrin Receptors And Ephrins
    [7]

    CSF-1 Receptor and v-fms
    [4]

    Other Receptor and Ligands
    [8]

    Pharmacogenomics and Drug Metabolism
    [6]

    Collaboration Management Articles (not peer reviewed)
    [6]
  • Lectures and Other Presentations

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    I've been invited to give talks on my work at a number of science conferences around the world. These are listed below and grouped by subject matter:

    Biology of the IL-4 Receptor:
    FASEB conference on Receptors, June 1990
    Biotechnological Applications in the 1990's, UC-Irvine, Irvine, CA, May 1990

    Biology of Steel Factor (c-
    kit Ligand):
    Armand Hammer Workshop: Regulation of Hematopoietic Stem Cells, La Jolla, CA, October 1990
    Nargis Dutt Memorial Symposium: Cytokines in Clinical Medicine, UC-Irvine, Irvine CA October 1990
    Stromal Regulation of Hematopoiesis, Bethesda, MD, June 1991
    Blood Cell Growth Factors Meeting, Beijing, China, August 1991
    American Society for Pediatric Hematology/Oncology, Chicago IL, September 1991
    AACR 43rd Annual Symposium on Fundamental Cancer Research: "Growth Factors and their Receptors in Cancer: Basic Mechanisms and Therapy" Houston, Texas, November 1991

    Biology of Flt3 Ligand:
    Plenary Session, 1993 American Society of Hematology meeting, St. Louis, MO. December, 1993
    Keystone Hematopoiesis Conference, Breckenridge, CO January, 1994
    Advances in Bone Marrow Transplantation, Valhalla, NY March 7, 1994
    Advances in Hematopoiesis Conference, Tokyo, Japan July 1994
    The Metcalf Forum: Polyfunctionality of Hematopoietic Regulators, Dublin, Ireland September 1994
    Mehdi Tavissoli Memorial Symposium: Hematopoietic Stem Cells, Reno, Nevada, November 1994
    Taniguchi Foundation Symposium: Regulation of Hematopoietic Stem Cells, Osaka, Japan, December 1994
    9th Symposium, Molecular Biology of Hematopoiesis, Genoa, Italy, June 24-27, 1995
    International Society for Experimental Hematology, Dusseldorf, Germany, August 26-31, 1995
    International Symposium on Bone Marrow Transplantation: Basic and Clinical Studies, Tokyo, Japan, October 9-10, 1995
    American Association for Cancer Research Satellite Symposium: Cytokines and Cytokine Receptors, Lake George, NY, October 1995
    Southern Blood Club, New Orleans, LA, February 1, 1996
    Wilsede Conference, Human Leukemia Meeting, Hamburg, Germany, June 14-18, 1996
    Research Trends in Hematopoietic Cell Culture, Tokyo, Japan, August 26-28, 1996
    Biological Therapy of Cancer, Munich, Germany, June 11-14, 1997
    IBC conference "Hematopoietic Stem Cells" San Diego, CA, June 23-24, 1997
    International Society for Experimental Hematology, Cannes, France, August 24-28, 1997
    Mini-symposium: Tyrosine kinase receptors, University of Lund, Sweden, August 29, 1997

    Research Collaborations:
    Challenges and Tensions in International Research Collaborations, Minneapolis, MN Oct. 2-3, 2008
    The 11th Annual Fred Hutchinson Cancer Research Center Bioethics Colloquium:
    Collaborative Science: How to Win Friends and Influence Research Seattle, WA May 23, 2011

    Bioethics:
    Fred Hutchinson Cancer Research Center
    Research Ethics Education Program:
    Strategies for Avoiding Ethical Problems in Your Science Career: Learn from the Mistakes of Others. Seattle, WA Nov. 16, 2011

    Accessing the Scientific Literature:
    Journals and Science: The Past, Present, & Future Impacts of Research Journals on Science
    Information Overload or Underload? University of Washington, Nov. 15, 2013

    Career Retrospective:
    "Looking Back: Lessons Learned from My First 35 Years in Research and Biotech." University of Washington Jan. 23, 2014. Video can be downloaded here.

    On the Radio:
    Several years ago I appeared as a guest on Seattle’s National Public Radio station KUOW’s Weekday program. The topic of the program was the potential ramifications of a recent court decision invalidating certain portions of patents held by Myriad Genetics on the BRCA1 and BRCA2 genes. This topic, focusing on whether or not genes should be patentable, led to an interesting discussion among the panel members, which also included Jon Izant of Sage Networks, Ulrich Mueller of the Fred Hutchinson Cancer Research Center, and Andrew Serafini of Fenwick and West. The segment aired on March 29, 2010 and you can listen to the recording by clicking here.

    Pacific NW Economic Region's Economic Leadership Forum - I moderated a panel discussion on Sept. 19, 2014 on "Building a Biotech Cluster."

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