I have assembled an updated list of Northwest drug-centered biotechnology companies for the benefit of the local biotech community. Also included here are companies headquartered elsewhere, but with research or manufacturing groups in our area. Publicly traded companies are in Bold. Hyperlinks will take you to the company websites; no hyperlink means no website. Please e-mail me any corrections or updates. Click here to see a list of these companies sorted by the technological approaches they have taken towards drug development. Click here to go to my Seattle Biotech Graveyard page detailing the fates of companies that are no longer with us in Seattle. Finally, click here to learn about my consulting services, or use the links on the left.

Most of the companies listed here are headquartered in the Puget Sound region, although the list also includes other WA State companies and a few in OR and Vancouver, BC.

13Therapeutics - Portland based anti-inflammatory peptide developer
AbSci - Portland based company develops and produces monoclonal antibodies
Acucela - Drug therapies for blinding eye diseases (Note: publicly traded on the Tokyo Stock Exchange)
Acylin Therapeutics - Small molecules targeted at histone acetyltransferases for cancer
Aequus BioPharma - Genetic polymer technology for biologics
Agave Pharma, Inc. - Unknown business focus
Ajuga Biosciences - Developing terpene based chemicals from mint
Alder Biopharmaceuticals - Yeast monoclonals to treat diseases
Algomedix - Focused on developing medicines for chronic pain
Allon Therapeutics - Focus on neurodegenerative diseases in BC
Allozyne - Protein modification technology to remake proteins
Alpine Biosciences - Immunotherapy startup in Seattle
Amgen - Multi-national protein-based biotech headquarters in CA
Aminex Therapeutics - Developing inhibitors of polyamine pathway
Amkor Pharma - Virtual biotech, clinical focus on neuroprotection
AmpliPhi - Seattle office of London based bacteriophage company
Anergix LLC - Developing peptide delivery MS treatments; admin office Seattle
ApoVax - Developing novel technologies for cancer and infectious diseases
Arrowsmith Technologies - Antibodies trap chemo for brain cancer
Artemisia BioMedical - Novel artemisinin-based therapeutics
Artielle Immunotherapeutics - Therapies for autoimmunity in OR
Arzeda - Uses computational approaches to make novel enzymes
Ave Maria (AVM) Biotech - Working on ethical human therapeutics
Beat BioTherapeutics - Working on repairing damaged hearts with stem cells
Bio Architecture Lab - Spinoff from David Baker's lab at the UW
Blaze Bioscience - Developing a “paint” to identify tumor cells
Bullet Biopharma - Start-up focused on the development of a proprietary platform, the BBP protein scaffold domain
Cancer Targeted Technology - Unique enzyme inhibitors
Cardeas Pharma - New startup of entrepreneur Bruce Montgomery; inhaled antibiotics
Cascade ProDrug - In Eugene, developing anticancer treatments
Celator Pharmaceutics - BC based combination oncology drugs
Cellcyte Genetics - Stem cell expansion bioreactor technology
Cell Therapeutics Inc - Developing small molecules for cancer
CisThera - Drugs for cancer, autoimmune disease, and others
CMC ICOS Biologics - contract biologics manufacturing
Cocrystal Discovery - Small molecule anti-viral drugs
Compliment Corp - Website under construction
Coronado Biosciences - Clinical stage cancer care company
Covance - Acquired Rosetta's gene expression laboratory
Dendreon - Vaccines for prostate cancer and other cancers
DesignMedix - Portland based drug combination company
Dimera - Portland based, discovering novel medical concepts
DuraThera - Developing treatments for osteoarthritis
Durable Therapeutics - No description available
Emergent BioSolutions - Developing small modular immunopharmaceuticals acquired from Trubion as well as vaccines
Etubics - Developing vector vaccines for infectious diseases
Fabion Pharmaceuticals - Startup focusing on developing bispecific antibodies for cancer treatment
Fate Therapeutics - Stem cell based therapies with HQ in CA
Floragenex - SNP discovery and genotyping in plants
Gamma Therapeutics - OHSU hematology/cardiology startup
Genimbi - Develops cloud based profiling tools for genomic DNA analysis
Genzyme - Manufactures and sells Leukine in US, HQ in MA
Gilead - Lung disease discovery group in Seattle; HQ in CA
Glycostasis Inc. - Drug development focused on diabetes care
Groove Biopharma (formerly Mirina) - Uses microRNA to develop new drugs
Halo-Bio RNAi Therapeutics - Novel asymmetric RNAi therapeutics
Helix BioMedix - Bioactive peptides for skin disorders, infections
Icogenex - Working to identify molecules for the treatment of neurodegenerative disease
Ikaria - Focus on metabolic depression and critical care medicine
ImaRxTherapeutics - Blood clot dissolving technology
Imdaptive - Profiles changes in the adaptive immune system
Immune Design - Developing therapeutics for infectious diseases
Immusoft - Technology platform to reprogram the immune system
Implicit Bioscience - Small molecule dipeptides as anti-microbials
Inimex Pharmaceuticals - Works on innate defense regulators (Canadian?)
Indel Therapeutics - Working on novel antibiotics
ISM Therapeutics - Therapeutics based on inositol signaling
Juno Therapeutics - Seattle/NY immunotherapy startup launched with $120M in 2013
Kaleetan Pharmaceuticals - Vaccine focused startup
KinDex Therapeutics - Focus on metabolic regulatory networks
Kineta - Small molecule drugs that enhance immunity
Koronis - Developing anti-viral drugs via viral decay methodologies
Light Sciences Oncology - Light activated oncology products
LigoCyte Therapeutics - Vaccine technologies based in MT
MalorVx - Novel vaccine approaches to eradicate malaria
M3 Biotechnology, Inc. - Regulating protein-protein interactions, based in Tumwater
Matrix Genetics - Engineering blue green algae to make renewable fuels
Metheor Therapeutics - Developing small molecule inhibitors of DNA methyltransferases
Mitotherix - FHCRC spinoff working on anti-cancer therapies
NanoQuantum - Works on photodynamic nanoparticles
Najit - Diagnostics, vaccines for developing countries; in Portland
NeuMedics - Developing drug to prevent Azheimer’s symptoms
North Coast Biologics - Rabbit high-affinity antibody based drugs
Novo Nordisk - Branch of Danish pharma focusing on immunity
Novo Nordisk Type 1 Diabetes Research and Development Center - opened June 2012
NW Biotherapeutics - Dendritic cell based cancer vaccines
Obenomics - Small molecule approach to treating obesity
Omeros - Clinical stage company, focus is on inflammation, CNS
Oncofactor - Accelerator startup focused on novel cancer therapy
Oncogenex - Small molecule based oncology drug pipeline
OncoMed Pharma - Therapies directed at cancer stem cells
Oncotherapy Solutions LLC - Developing anti-cancer drugs for solid tumors
Oncothyreon (formerly Biomira) - Oncology drugs and vaccines
Ondine Research - Vancouver CA based anti-infective therapies
Onkor Pharmaceuticals - Virtual company making cancer drugs
Oricula Therapeutics - Developing medicines to protect hearing
Pacific Northwest Biotechnology - Small molecule drug discovery
PharmAthene - Merging with Theraclone in 2013; will focus on antibody drug development and vaccines; HQ in Seattle
PharmIn - Copolymer drug delivery platform technology
PhaseRx - Multi-functional polymers to aid drug delivery
PhotoMedex - Skin care products using copper peptide technology
Phytelligence - Fruit plantlet genetics and propagation
Poniard was to be acquired by Allozyne in 2011 in order to acquire a listing on the NASDAQ and thereby go public. However, the deal did not go through and was terminated Dec. 22, 2011
Precision Genome Engineering - Making genomic changes and custom organisms
Pregenen - Endonuclease based technologies for treating disease
ProFibrix - Drugs for hemostasis and regenerative medicine
ProteoTech - Small molecule development for amyloid diseases
Protein Advances Inc - Bioinformatics based vaccine discovery
Qwell - Developing small molecule drugs from plant sources
Rain BioScience - Developing drugs for difficult to treat diseases using a delivery technology for RNA-targeting oligomers
Recodagen - Targets mechanisms that allow cancer metastasis
Resolve Therapeutics - Start up developing a lupus drug
Revalesio Corporation - Developing treatments for inflammatory disease
RJS Biologics - Adds affinity-tags to drive therapeutic compounds into cancer cells
Seattle Genetics - Monoclonal antibodies for cancer treatment
Seattle Life Sciences - Zymogenetics spin-off in 2009; may no longer be in business
Seredigm - Biological therapeutics for ischemia/reperfusion injury
Sound Pharmaceuticals - Drugs to prevent hearing loss
Spiral Genetics - Open source based bioinformatics products
Stella Therapeutics - Developing a treatment for glioblastoma multiforme
Syntrix Biosystems - Novel therapeutics and research platforms
SystImmune - Newly established antibody therapeutics company
TapImmune - Developing vaccines for oncology and infections
Tekmira - RNAi drugs for cancer and cholesterol; BC based
Theraclone Sciences (was Spaltudaq) - Developing therapeutic antibodies; ended potential merger with PharmAthene in 2013
The Gene Pool, Inc - Molecular locks based drug discovery
TRIA Biosciences - Advancing innovative treatments for infection and chronic disease
Valocor Therapeutics - BC based dermatology drug developer
V-Gene - Antibody based drug development
Viva Biopharm - Manufacturing plant in Blaine for BC company
VentiRx - Developing new small molecule drugs for cancer, ID
Virtici Corporation - Startup with an unknown plan
WA 32609 - Holding company, acquired ischemic stroke therapy
Xori - Making antibodies in chicken cells for faster, cheaper drugs
Zymeworks - BC based computational biology drug platform