I have assembled an updated list of Northwest drug-centered biotechnology companies for the benefit of the local biotech community. Also included here are companies headquartered elsewhere, but with research or manufacturing groups in our area. Publicly traded companies are in
Bold. Hyperlinks will take you to the company websites; no hyperlink means no website. Please e-mail me any corrections or updates. Click here to see a list of these companies sorted by the technological approaches they have taken towards drug development. Click here to go to my Seattle Biotech Graveyard page detailing the fates of companies that are no longer with us in Seattle. Finally, click here to learn about my consulting services, or use the links on the left.

Most of the companies listed here are headquartered in the Puget Sound region, although the list also includes other WA State companies and a few in OR and Vancouver, BC.

13Therapeutics - Portland based anti-inflammatory peptide developer
AbSci - Portland based company develops and produces monoclonal antibodies
Achieve Life Sciences was
created in Jan. 2017 by reverse merger of OncoGenex and Achieve; works on cancer and smoking cessation drugs
Acucela - Drug therapies for blinding eye diseases (Note: publicly traded on the Tokyo Stock Exchange)
Aequus BioPharma - Developing improved version of the drug ACTH by fusing it to NDP-MSH. It appears to have deemphasized its work on genetic polymer technology for biologics
Agave Pharma, Inc. - RNAi therapeutics and delivery
Ajuga Biosciences - Developing terpene based chemicals from mint
Akeaso Immunotherapeutics - Focused on development antibody drug conjugates to modify the behavior of inflammatory lymphocytes
Alder Biopharmaceuticals - Yeast monoclonal antibodies to treat diseases
Algomedix - Focused on developing small molecule medicines for chronic pain
Allon Therapeutics - Focus on neurodegenerative diseases in BC
Alpine Immune Sciences - Immunotherapy company headed by former Dendreon CEO Mitch Gold (went public via merger in 2017)
Aminex Therapeutics - Developing inhibitors of polyamine pathway
Amkor Pharma - Virtual biotech, clinical focus on neuroprotection
AmpliPhi - Seattle office of London based bacteriophage company for bacterial infections
Anergix LLC - Developing peptide delivery MS treatments; admin office in Seattle
Apogen Biotechnologies - Accelerator company developing drugs to combat cancer drug resistance in tumors by inhibiting a DNA cytosine deaminase enzyme
Aptevo Therapeutics - Emergent BioSolutions spin-off expected to launch in mid 2016, using technology acquired from Trubion
Arbutus Biopharma (formerly Tekmira) - BC developer of antiviral drugs
Arrowsmith Technologies - Antibodies trap chemo for brain cancer
Artemisia BioMedical - Novel artemisinin-based therapeutics
Artielle Immunotherapeutics - Therapies for autoimmunity in OR
Arzeda - Uses computational approaches to make novel enzymes
Atossa Genetics - Working up breast cancer catheters and drugs
Aurelius Biotherapeutics - Emerging veterinary immunotherapeutic and diagnostic company focused on immunoreconstitution for the treatment of malignancies
Ave Maria (AVM) Biotech - Working on ethical human therapeutics
Beat BioTherapeutics - Working on repairing damaged hearts with stem cells
Bio Architecture Lab - Spinoff from David Baker's lab at the UW is engaged in the development of low cost, scalable, and sustainable biomass
Blaze Bioscience - Developing a “paint” to identify tumor cells
Bullet Biopharma - Start-up focused on the development of a proprietary platform, the BBP protein scaffold domain
Cancer Targeted Technology - Unique small molecule enzyme inhibitors
Cardeas Pharma - New startup of entrepreneur Bruce Montgomery; inhaled antibiotics
Cascade ProDrug - In Eugene, developing vinca alkaloid derivatives as anticancer treatments
Cascadia Life Sciences - Unknown focus
Cascadian Therapeutics (formerly known as Oncothyreon, and before that Biomira) - Developing oncology drugs
Celator Pharmaceutics - BC based developer of combination oncology products
Celgene - Seattle branch of multinational drug company
CisThera - Drugs for cancer, autoimmune disease, and others
Clene Nanomedicine - Developing drugs based on a nano suspension technology
CMC ICOS Biologics - contract biologics manufacturing
Cocrystal Discovery - Small molecule anti-viral drugs
Compliment Corp - Novel engineered proteins derived from the non-immunogenic portion of adenoviruses that increase the efficacy and decrease the toxicity of widely used cancer therapies
CTI Biopharma (formerly Cell Therapeutics Inc) - Developing small molecules for cancer
CytoDyn - Develops monoclonal antibodies for treating HIV (Vancouver, WA)
DesignMedix - Portland based small molecule drug combination company
Dimera - Portland based, discovering small molecules for coronary heart disease in women
DMD Therapeutics - New start-up headed by serial entrepreneur Ron Berenson
Durable Therapeutics - No description available
Emergent BioSolutions - Developing small modular immunopharmaceuticals acquired from Trubion as well as vaccines
EpiThany - Immunotherapy startup to commercialize work of Nora Disis for cancer therapies
Etubics - Developing vector vaccines for infectious diseases
Fabion Pharmaceuticals - Startup focusing on developing bispecific antibodies for cancer treatment
Faraday Pharmaceuticals - Developing elemental reducing agents for protection against reperfusion injury
Floragenex - Genomic services: discovery, genotyping, and analytics
Gamma Therapeutics - Drugs and diagnostics platform built around clotting protein gamma prime fibrinogen
Genoa Pharmaceuticals - Bruce Montgomery led startup working on inhaled drugs for respiratory diseases
Genzyme - Manufactures and sells Leukine in US, HQ in MA
Gilead - Lung disease discovery group in Seattle; HQ in CA
Good Therapeutics, Inc. - Developing biotherapeutic proteins that regulate their own activity in response to metabolic signals
Halo-Bio RNAi Therapeutics - Novel asymmetric RNAi therapeutics
Helix BioMedix - Bioactive peptides for skin disorders, infections
Icogenex - Working to identify molecules for the treatment of neurodegenerative disease
Imdaptive - Profiles changes in the adaptive immune system
Immune Design - Developing immuno-oncology therapeutics and vaccines
Immusoft - Technology platform to reprogram the immune system
Implicit Bioscience - Small molecule dipeptides as anti-microbials and mAbs
Integrated Diagnostics - Developed a molecular blood test for assessment of pulmonary nodules
ISM Therapeutics - Therapeutics based on inositol signaling
Juno Therapeutics - Seattle/NY immunotherapy startup launched with $120M in 2013
Just Therapeutics - Expanding patient access to biotherapeutics via innovative cost savings solutions
KinDex Therapeutics - Focus on metabolic regulatory networks
Kineta - Small molecule drugs that enhance immunity
KPI Therapeutics - Developing drugs for autoimmunity; aligned with Seattle biotech Kineta
Light Sciences Oncology - Light activated oncology products
MalorVx - Novel vaccine approaches to eradicate malaria
M3 Biotechnology, Inc. - Regulating protein-protein interactions for treating Parkinson's and Alzheimer's diseases; WSU spinout located in Fluke Hall at the UW in Seattle
Matrix Genetics - Engineering blue green algae to make renewable fuels
Metheor Therapeutics - Developing small molecule inhibitors of DNA methyltransferases
Mitotherix - FHCRC spinoff working on anti-cancer therapies
Najit - Diagnostics, vaccines for developing countries; in Portland
NeuMedics - Developing drug to prevent Azheimer’s symptoms
Nohla Therapeutics - Fred Hutch spin out developing umbilical cord blood for transplants and restoring white blood cells
North Coast Biologics - Rabbit high-affinity antibody based drugs
Novo Nordisk Obesity Research Unit - Opening in Seattle 2015
Obenomics - Small molecule approach to treating obesity
Omeros - Clinical stage company, focus is on inflammation, CNS
Oncofactor - Accelerator startup focused on novel cancer therapy
OncoMed Pharma - Therapies directed at cancer stem cells
OncoResponse - Based in Seattle/Houston, screens B cell responses of cancer “Elite Responders” to uncover new targets/antibodies for immunotherapy
Oncotherapy Solutions LLC - Developing anti-cancer drugs for solid tumors
Onkor Pharmaceuticals - Virtual company making cancer drugs
Oricula Therapeutics - Developing medicines to protect hearing
Pacific Northwest Biotechnology - Small molecule drug discovery
PAI Life Sciences (formerly Protein Advances Inc. - Developing protein biotherapeutics
Pembient - Bioengineering wildlife products in order to save wildlife
PharmAthene - Merging with Theraclone in 2013; will focus on antibody drug development and vaccines; HQ in Seattle
PhaseRx - Multi-functional polymers to aid drug delivery; IPO May 2016
Phytelligence - Fruit plantlet genetics and propagation
ProFibrix - Drugs for hemostasis and regenerative medicine
ProteoTech - Small molecule development for amyloid diseases
PvP Biologics - Aiming to commercialize an orally taken enzyme that breaks down gluten for treating celiac disease. Labs are in Seattle, with management in San Diego.
Qwell - Developing small molecule drugs from plant sources
RAiN Bioscience - Developing drugs for difficult to treat diseases using a delivery technology for RNA-targeting oligomers
Resolve Therapeutics - Start up developing a protein based drug to treat lupus
Revalesio Corporation - Developing treatments for inflammatory disease
RJS Biologics - Adds affinity-tags to drive therapeutic compounds into cancer cells
Rodeo Therapeutics - Developing 15-PGDH inhibitors for the treatment of IBD and promoting blood cell reconstitution after bone marrow transplant
Seattle Genetics - Monoclonal antibodies for cancer treatment
Seattle Life Sciences - Zymogenetics spin-off in 2009; may no longer be in business
Silverback - Peter Thompson’s new biotech (launched in 2016), still in stealth mode
Sound Biologics - Biotech company with a focus on cancer, inflammatory and autoimmune diseases
Sound Pharmaceuticals - Drugs to prevent hearing loss
Stella Therapeutics - Developing a treatment for glioblastoma multiforme
Syntrix Biosystems - Novel therapeutics and research platforms for treating pain
SystImmune - Newly established antibody therapeutics company focused on cancer treatments
Theraclone Sciences (was Spaltudaq) - Developing therapeutic antibodies for pandemic and seasonal influenza; ended potential merger with PharmAthene in 2013
The Gene Pool, Inc - Molecular locks based drug discovery
TomegaVax - Developing vaccines and immunotherapies for viral infections in Beaverton, OR
TRIA Biosciences - Advancing immune-based innovative treatments for infection and chronic disease
Twin Strand Biosciences - Uses duplex sequencing technology to improve detection of DNA mutations; CEO is Seattle biotech veteran Michael Kranda
UbiVac - Portland based developer of therapeutic vaccines for cancer and infectious diseases
Universal Cells - Off the shelf universal donor stem cells
V-Gene - Antibody based drug development
VentiRx - Developing drugs for cancer, infectious diseases
Virvio - Working on the development of novel computationally designed proteins to treat influenza
Virtici Corporation - Startup with an unknown plan
WA 32609 - Holding company, acquired ischemic stroke therapy
Zymeworks - BC based computational biology drug platform for creating antibodies and protein therapeutics

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